HEPATOTOXIC AND CARDIOTOXIC EFFECTS OF TESTOSTERONE ENANTHATE ABUSE ON ADULT MALE ALBINO RATS

Background: Anabolic androgenic steroids (AASs) represent a group of synthetic derivatives testosterone created to maximize anabolic effects and minimize the ones. Athletes use (AAS) enhance performance regardless health risk they may impact in some persons. Objective: To study histopathological biochemical changes that could occur on liver cardiac muscle after administration doping dose (supraphysiological dose) enanthate (one AAS). Materials Methods: One hundred (100) male albino rats were included present divided into six groups. Group (1a); negative control group, (1b) positive treated with therapeutic Enanthate (10 mg /Kg body weight intramuscular / I.M weekly for 12 weeks), (2) was (60 weight/ 4 (3) 8 (4) (5a) I.M/ weeks followed by 2 of  treatment discontinuation) , (5b) discontinuation). Blood samples collected at start end study. Liver enzymes measured usual methods. At each animals sacrificed deeply anesthetized diethyl ether then specimens from heart processed histological using light microscope. Results: There no statistical significant difference between group. In contrast, administering (group III-IV) showed decrease compared II (P < 0.05). recovery Va Vb) when (p value current as regard level biomarkers (ALT-AST) had gradual increase all through experimental periods. creatinine kinase (CK) CK-MB groups versus most P Conclusion: Chronic supraphysiological (doping has toxic effect rat form alteration normal histology, hypertrophy fibrosis both levels which lead loss their functions. This partially reversible cessation treatment.